Recent Publications from Dr. Tad H. Koch's Lab

at The University of Colorado's Department of Chemistry and Biochemistry

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• Koch, T.H.; Barthel, B.L.; Kalet, B.T.; Rudnicki, D.L.; Post, G.C.; Burkhart, D.J. "Anthracycline-formaldehyde Conjugates and Their Targeted Prodrugs", Topics in Current Chemistry 2007, electronic version.
• Spencer, D.M.; Bilardi, R.A.; Koch, T.H.; Post, G.C.; Nafie, J.W.; Kimura, K.-I.; Cutts, S..; Phillips, D.R. "DNA Repair in Response to Anthracycline-DNA Adducts: A Role for both Homologous Recombination and Nucleotide Excision Repair", Mutation Res. 2008, 638, 110-121.
• Barthel, B.L.; Torres, R.C.; Hyatt, J.L.; Edwards, C.C.; Hatfield, M.J.; Potter, P.M.; Koch, T.H. "Identification of Human Intestinal Carboxylesterase as the Primary Enzyme for Activation of a Doxazolidine Carbamate Prodrug", J. Med. Chem. 2008, 51, 298-304.
• Kalet, B.T.; McBryde, M.B.; Espinosa, J.M.; Koch, T.H. "Doxazolidine Induction of Apoptosis by a Topoisomerase II Independent Mechanism", J. Med. Chem. 2007, 50, 4493-4500.
• Burkhart, D.J.; Barthel, B.L.; Post, G.C.; Kalet, B.T.; Nafie, J.W.; Shoemaker, R.K.; Koch, T.H. "Design, Synthesis, and Preliminary Evaluation of Doxazolidine Carbamates as Prodrugs Activated by Carboxylesterases", J. Med. Chem. 2006, 49, 7002-7012.
• Post, G.C.; Barthel, B.L.; Burkhart, D.J.; Hagadorn, J.R.; Koch, T.H. "Doxazolidine, a Proposed Active Metabolite of Doxorubicin That Cross-links DNA", J. Med. Chem. 2005, 48, 7648-7657.
• Burkhart, D.J.; Kalet, B.T.; Coleman, M.P.; Post, G.C.; Koch, T.H. "Doxorubicin-formaldehyde Conjugate Targeting µ_vb₃ Integrin", Mol. Cancer Therap. 2004, 3, 1593-1604.
• Burke, P.J.; Kalet, B.T.; Koch, T.H. "Antiestrogen Binding Site (AEBS) and Estrogen Receptor (ER) Mediate Uptake and Distribution of 4-Hydroxytamoxifen-targeted Doxorubicin-formaldehyde Conjugate in Breast Cancer Cells" J. Med. Chem. 2004, 47, 6509-6518.
• Cogan, P.S.; Koch, T.H. "Studies of Targeting and Intracellular Trafficking of an Anti-Androgen-Doxorubicin-Formaldehyde Conjugate in PC-3 Prostate Cancer Cells Bearing Androgen Receptor-GFP Chimera", J. Med. Chem. 2004, 47, 5690-5699.
• Cogan, P.S.; Fowler, C.R.; Post, G.C.; Koch, T.H. "Doxsaliform: A novel N-Mannich base prodrug of a doxorubicin-formaldehyde conjugate", Lett. Drug Design Dis., 2004, 1, 247-255.
• Burke, P.J.; Koch, T.H. "Design, Synthesis, and Biological Evaluation of Doxorubicin-Formaldehyde Conjugates Targeted to Breast Cancer Cells" J. Med. Chem. 2004, 47, 1193-1206.
• Koch, T.H.; Smith, D.; Tabacman, E.; Zichi, D. A. "Kinetic Analysis of Site-specific Photoaptamer-Protein Cross-Linking" J. Mol. Biol., 2004, 336, 1159-1173.
• Cogan, P.S.; Koch, T.H. "Rational Design and Synthesis of Androgen Receptor Targeted Non-Steroidal Anti-Androgen Ligands for the Tumor Specific Delivery of a Doxorubicin-Formaldehyde Conjugate", J. Med. Chem. 2003, 46, 5258-5270.
• Smith, D.; Collins, B. D.; Heil, James, Koch, T. H. "Sensitivity and Specificity of Photoaptamer Probes" Mol. Cell. Proteomics, 2003, 2.1, 11-18.
• Golden, M. C.; Collins, B. D.; Willis, M. C.; Koch, T. H. "Selection of Highly Specific and Sensitive ssDNA Photocross-Linking Aptamers to Target Proteins Using PhotoSELEX and Their Diagnostic Potential", in Gene Cloning and Expression Technologies (Weiner, M. P.; Lu, Q., eds), Eaton Publishing, Westborough, MA, 2002, pp 477-491.
• Kato, S.; Post, G. C.; Bierbaum, V. M.; Koch, T. H. "Chemical Ionization Mass Spectrometric Determination of Acrolein in Human Breast Cancer Cells", Anal. Biochem., 2002, 305, 251-259.
• Dernell, W. S.; Powers, B. E.; Taatjes, D. J.; Cogan, P.; Gaudiano, G.; Koch, T. H. "Evaluation of the Epidoxorubicin-formaldehyde Conjugate, Epidoxoform, in a Mouse Mammary Carcinoma Model" Cancer Invest., 2002, 20, 713-724.
• Kato, S.; Burke, P. J.; Koch, T.; Bierbaum, V. M. "Formaldehyde in Human Cancer Cells: Sensitive Detection by Distillation Sampling-Chemical Inoization Mass Spectrometry and Prognostic Implications" Anal. Chem., 2001, 73, 2992-2997.
• Burke, P. J.; Koch, T. H. "Doxorubicin-formaldehyde Conjugate, Doxoform: Induction of Apoptosis Relative to Doxorubicin" Anticancer Res., 2001, 21:4A, 2753-2760.
• Kato, S.; Burke, P. J.; Fenick, D. J.; Taatjes, D. J.; Bierbaum, V. M.; Koch, T. H. "Mass Spectrometric Measurement of Formaldehyde Generated in Breast Cancer Cells upon Treatment with Anthracycline Antitumor Drugs" Chem. Res. Toxicol., 2000, 13, 509-516.
• Taatjes, D. J.; Koch, T. H. "Nuclear Targeting and Retention of Anthracycline Antitumor Drugs in Sensitive and Resistant Tumor Cells", Current Med. Chem., 2001, 8, 15-29.
• Golden, M. C.; Collins, B. D.; Willis, M. C.; Koch, T. H. "Diagnostic Potential of PhotoSELEX-Evolved ssDNA Aptamers", J. Biotechnol., 2000, 81, 167-178.
• Gaudiano, G.; Koch, T. H.; Lo Bello, M.; Nuccetelli, M.; Ravagnan, G.; Serafino, A.; Sinibaldi-Vallebona, P. "Lack of Glutathione Conjugation to Adriamycin in Human Breast Cancer MCF-7/DOX Cells", Biochem. Pharm., 2000, 60, 1915-1923.
• Podell, E. R.; Harrington, D. J.; Taatjes, D. J.; Koch, T. H. "Crystal Structure of Epidoxorubicin-formaldehyde Virtual Crosslink of DNA and Evidence for Its Formation in Human Breast Cancer Cells", Acta Cryst. D, 1999, D55, 1516-1523.
• Meisenheimer, K. M.; Meisenheimer, P. L.; Koch, T. H. "Nucleoprotein Photocrosslinking Using Halopyrimidine-Substituted RNAs", Methods in Enzymol., 2000, 318, 88-104.